Web5 de ago. de 2024 · This study also identified PPP1R1B, a gene negatively regulated by HIF1A, as a key promoter of metastasis in pancreatic cancer. Elevated expression of PPP1R1B has been associated with advanced disease and poor prognosis in several cancers, including breast and lung cancer. Web4 de nov. de 2024 · Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that facilitates the adaptation of cancer cells to hypoxic conditions and may be prognostic of …
Extracellular ATP promotes breast cancer chemoresistance via HIF …
Web8 de jul. de 2024 · Significance. We demonstrated that early B cell factor 1 (EBF1) is highly expressed in triple-negative breast cancer (TNBC) cells, and knockdown of EBF1 … Web9 de jul. de 2015 · Tamoxifen resistance is often observed in the majority of estrogen receptor–positive breast cancers and it remains as a serious clinical problem in breast cancer management. Increased aerobic glycolysis has been proposed as one of the mechanisms for acquired resistance to chemotherapeutic agents in breast cancer cells … cindy\u0027s olive oil company
XBP1 promotes triple-negative breast cancer by controlling …
Web25 de jan. de 2024 · miR-153 inhibits hypoxia-induced HIF1α expression in breast cancer cells. There is a consensus miR-153-binding site at the HIF1A-3′-UTR (Fig. 1a).To test whether miR-153 directly targets HIF1α ... Web5 de ago. de 2016 · Breast cancer is the most frequently diagnosed form of cancer in American women and is the second leading cause of cancer-related deaths, primarily due to the incurable nature of metastatic breast cancer [].Metastasis is the process whereby cancer cells spread from the site of the original tumor to distant organs [].A stepwise … Web23 de nov. de 2024 · Breast cancer is a frequently diagnosed cancer, and the leading cause of cancer-related death among women worldwide (Torre et al., 2024). Breast cancer has been classified by the presence of hormone receptors, with molecular subtypes being based on the tumor cell expression of estrogen receptor (ER), progesterone receptor … cindy\u0027s olive oil